Model Generated by GINsim on 21 June 2013 12:42:26 CEST, by removing the following nodes: MEK1_2, PLCG, AP1, GAB1, TGFBR, ATF2, GRB2, MDM2, SOS, ATM, p21, PDK1, p38, TAOK, PPP2CA, BCL2, RSK, JNK, ELK1, SPRY, FOXO3, MTK1, RAS, MYC, RAF, p70, CREB, MAX, JUN, SMAD, MAP3K1_3, DUSP1, PKC, GADD45, FOS, TAK1 Logical model representing MAPK cascades activation following EGFR, FGFR3, TGFBR and DNA damage stimuli. Proliferation, Apoptosis and Growth arrest outputs (in blue) provide a readout of the contributions of the three main MAPK pathways (ERK, p38, JNK) to cell fate decision. Input signals are emphasised in pink, whereas the reference MAPK are emphasised in lila.

TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 0 AKT 0 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 1 AKT 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 1 AKT 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 1 AKT 0 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 1 AKT 0 TGFBR_stimulus 1 ERK 0 p53 1 AKT 0 p53 1 AKT 0 TGFBR_stimulus 0 DNA_damage 0 ERK 1 PI3K 1 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 0 PI3K 1 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 1 PI3K 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 1 PI3K 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 1 PI3K 1 AKT 1 MSK 1 TGFBR_stimulus 1 ERK 1 p53 0 PI3K 1 MSK 1 TGFBR_stimulus 1 ERK 1 p53 1 PI3K 1 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 0 EGFR 0 FGFR3 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 0 EGFR 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 1 AKT 0 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 1 AKT 1 MSK 0 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 1 AKT 0 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 1 AKT 1 MSK 0 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 1 AKT 0 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 1 AKT 1 MSK 0 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 0 MSK 0 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 1 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 1 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 1 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 0 EGFR 0 FGFR3 1 AKT 0 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 0 EGFR 0 FGFR3 1 AKT 1 MSK 0 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 0 EGFR 1 AKT 0 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 0 EGFR 1 AKT 1 MSK 0 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 1 EGFR 0 FGFR3 0 MSK 0 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 1 EGFR 0 FGFR3 1 p14 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 1 EGFR 1 p14 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 0 AKT 0 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 0 AKT 1 MSK 0 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 0 AKT 1 MSK 1 p14 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 0 AKT 0 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 0 AKT 1 MSK 0 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 0 AKT 1 MSK 1 p14 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 1 TGFBR_stimulus 1 DNA_damage 0 p53 0 AKT 0 TGFBR_stimulus 1 DNA_damage 0 p53 0 AKT 1 p14 1 TGFBR_stimulus 1 DNA_damage 0 p53 1 p14 1 TGFBR_stimulus 1 DNA_damage 1 EGFR_stimulus 0 TGFBR_stimulus 0 ERK 1 EGFR 0 FGFR3 0 FRS2 0 EGFR_stimulus 1 TGFBR_stimulus 0 EGFR 0 FGFR3 0 FRS2 0 FGFR3_stimulus 1 TGFBR_stimulus 0 EGFR 0 FGFR3 0 FRS2 0 TGFBR_stimulus 0 ERK 0 EGFR 0 FGFR3 1 FRS2 0 TGFBR_stimulus 0 EGFR 0 FRS2 0 PI3K 1 TGFBR_stimulus 0 EGFR 0 FRS2 1 TGFBR_stimulus 0 EGFR 1 TGFBR_stimulus 1 PI3K 1 PTEN 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 1 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 0 FGFR3 1 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 EGFR 1 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 0 MSK 0 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 0 MSK 0 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 TGFBR_stimulus 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 0 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 0 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 0 FRS2 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 0 FGFR3 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 0 p53 1 EGFR 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 0 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 1 EGFR 0 FGFR3 0 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 1 EGFR 0 FGFR3 1 MSK 1 TGFBR_stimulus 0 DNA_damage 0 ERK 1 p53 1 EGFR 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 0 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 0 FRS2 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 0 FGFR3 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 0 EGFR 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 0 p53 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 0 AKT 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 0 FGFR3 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 0 EGFR 1 MSK 1 TGFBR_stimulus 0 DNA_damage 1 ERK 1 p53 1 MSK 1 TGFBR_stimulus 1 MSK 1 p53 1